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From BMI to BCP: Body Composition Profiling with MRI for Metabolic Disease Management, Health Risks & Healthy Lifestyle Choices

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In the search to understand metabolic disease, prevention and treatments, people are often broadly categorized using relatively crude tools. This removes the individualized perspective. For example, obesity is commonly described using BMI (body mass index – weight in kg / height in m2), and individuals are placed in one of five categories ranging from underweight to obesity. However, the health risks related to obesity are more closely linked with body composition — which is the amount of muscle and fat in the body — than with generalized anthropometric measurements, such as body weight, BMI and waist circumference. The use of such broad, discrete categories like obesity, overweight, normal weight and underweight, or even high liver fat / low liver fat, to describe individuals should be questioned. Such categorizations run the risk of grouping individuals with little resemblance to one another, lacking both accuracy and precision for appropriate metabolic disease identification and management. In this webinar, the speakers introduce body composition profiling with magnetic resonance imaging (MRI) as an effective tool to manage metabolic disease state.

Among adiposity-related biomarkers currently used for health evaluation, BMI is recommended to identify individuals at increased risk of coronary heart disease and related comorbidities such as Type 2 Diabetes. Although a high BMI correlates with future health risks and predicts morbidity and death on a population scale, it is not effective on an individual scale. Recent research has significantly linked specific fat distributions to adverse cardiometabolic health outcomes, diabetes and liver disease, something that BMI fails to fully describe. In addition, there is heterogeneity in the manifestation of abdominal obesity in fat deposits such as liver, visceral and subcutaneous fat. Further, skeletal muscle is important in this context. Both fatty infiltration and lean muscle volume — or lack thereof, e.g., sarcopenia — are important in metabolic diseases, and are more commonly associated with aging and advanced disease states. Such specific body composition and fat distributions are not assessable using BMI, but can be effectively and precisely described using magnetic resonance imaging MRI-based body composition profiling.

Body composition profiling therefore, greatly individualizes the description of the individual, identifying potential hidden health risks and bringing us one step closer to precision medicine related to both assessment and targeted interventions. In this webinar, the featured speakers — clinical and imaging experts — will review the latest research on the impact of different body composition profiles on metabolic health, disease risk and metabolic disease treatment and development. There will be a special focus on the biologic and clinical perspectives, including why body composition matters and how it can be used to guide treatment.

Join this webinar to gain insights into body composition profiling with MRI, how such measurements have been used in recent research and the recent advancements that have made MRI-based body composition profiling available for clinical use nowadays.

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WEBINAR DATE

21 June 2022

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Carla Prado, PhD, RD

Professor of Human Nutrition

Dr. Carla Prado is a Professor at the University of Alberta in Canada and a Campus Alberta Innovate Program (CAIP) chair in nutrition, food and health. She is also the Director of the Human Nutrition Research Unit. She is an expert in assessing nutritional status through the precise measurement of body composition and energy metabolism. The focus of her current research program is to develop targeted nutrition interventions for the prevention and treatment of low muscle mass in patients with cancer. She is currently the Principal Investigator for three clinical trials investigating the impact of nutrition intervention on body composition and health. She is an editorial board member of Clinical Nutrition, the Journal of Cachexia, Sarcopenia and Muscle and Current Opinion in Clinical Nutrition and Metabolic Care. Dr. Prado is a past recipient of Canada’s Top 40 Under 40, an award that celebrates exceptional young Canadian leaders of all sectors, and she was recently inducted into the Royal Society of Canada, the highest academic honor in her country.

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Ian J. Neeland, MD

Director of Cardiovascular Prevention, University Hospitals; Associate Professor of Medicine, Case Western Reserve University

Co-Director of the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease

Ian J. Neeland, MD, is Director of the University Hospitals Center for Cardiovascular Prevention, Director of the Translational Science Unit, and Co-Director of the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease (CINEMA program) for University Hospitals Harrington Heart & Vascular Institute and Associate Professor of Medicine at Case Western Reserve University School of Medicine in Cleveland, Ohio. He is a General and Preventive Cardiologist with special expertise in obesity, diabetes and prevention of cardiovascular disease. Dr. Neeland is a Fellow of the American Heart Association and American College of Cardiology and serves on several national committees with the American Heart Association. He is an active Clinical and Translational Investigator with funding from the National Institutes of Health and industry. He has published over 110 scholarly articles and delivered a number of national, international and regionally invited lectures. He is a reviewer for many respected journals, including Circulation, for which he currently serves as an Associate Editor and Section Editor for Bridging Disciplines.

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Mikael F. Forsgren, PhD

Senior Scientist

Liver Disease Lead Scientist

Mikael Forsgren is the Lead Scientist for liver diseases at AMRA Medical with the responsibility of developing and leading liver disease application projects. He has been involved in liver-related research using magnetic resonance (MR) imaging and spectroscopy since 2009 — both in academia and industry. He has a MSc in biotechnology and PhD in medical sciences. In his doctoral thesis he explored MR methods to replace the liver needle biopsy and quantify liver function. In addition to exploring body composition in liver diseases, he has applied his MR expertise to assess body composition in COPD, fibromyalgia syndrome and in general populations. Prior to joining AMRA in 2017 he worked as a consultant for Wolfram MathCore, where he collaborated with several pharma companies, academic institutions and the US Food and Drug Administration. He currently holds an adjunct position at Linköping University and is a member of the university’s Center for Medical Image Science and Visualization.

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What you will learn
  • The impact of different body composition profiles on metabolic health, disease risk and metabolic disease treatment and development
  • How body composition can be used to guide treatment
Who should attend?
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