• Skip to primary navigation
  • Skip to main content
AMRA MedicalAMRA Medical

AMRA Medical

Precision for Decision

  • Career
  • Support
  • Contact Us
  • Solutions
    • Clinical Services
    • Research Services
  • Get Set Up
    • Get Set Up
    • Get a Quote
  • Science
    • What We Do
    • How We Do It
    • Why It Matters
    • Our Core Areas
    • Technology
  • News & Events
    • News
    • Events
  • Resources
    • Webinars
    • Publications
    • Whitepapers
    • Media
  • About Us
    • About AMRA
    • Our Team
    • Partners & Investors
  • Career
  • Support
  • Contact Us

AMRA Medical’s MRI-based Biomarkers Validated in the FNIH’s NIMBLE Study

October 25, 2023
  • Facebook
  • Twitter
  • LinkedIn
  • Mail

LINKÖPING, Sweden, October 25, 2023 – Visceral fat, also known as Visceral Adipose Tissue (VAT), is the adipose tissue inside the abdominal cavity. VAT is a central risk factor for Non-Alcoholic Fatty Liver Disease (NAFLD), liver cirrhosis, cardiovascular disease (CVD), and type-2 diabetes (T2D). This study validates, prospectively, the precision and repeatability of AMRA Medical’s VAT biomarker for use in clinical trials.

Approximately 25% of the general population has NAFLD and a subset is affected by the more advanced form NASH (nonalcoholic steatohepatitis). Patients with NASH are at risk of liver-related and cardiovascular morbidity. There is an unmet need to identify those patients at risk and to facilitate clinical trials using non-invasive methods.

The FNIH’s (Foundation for the National Institutes of Health) NIMBLE consortium (Non-invasive Biomarkers of Metabolic Liver Disease) is a collaborative research effort that aims to standardize, compare, and validate biomarkers for the non-invasive diagnosis and monitoring of NAFLD and NASH. NIMBLE partners with major pharmaceutical companies, academic centers, and key opinion leaders in industry, to evaluate candidate biomarkers for their suitability for wider implementation in clinical trials. AMRA Medical’s VAT biomarker was chosen as one of the primary biomarkers in the NIMBLE 1.2 study, showing excellent repeatability in patients with NAFLD.

The NIMBLE 1.2 study was designed to assess the potential of using MRI-based biomarkers longitudinally in NAFLD/NASH clinical trials. In this first paper, published by Fowler et al. in Radiology, the repeatability of liver fat, liver stiffness, and VAT was assessed in patients with NAFLD. AMRA’s VAT biomarker was assessed as the primary body composition biomarker, due to the connection between obesity, CVD, insulin resistance, and NAFLD. Data on other body composition biomarkers and metrics from AMRA have also been collected and will be reported in a future paper.

This study found that AMRA’s VAT biomarker was reproducible across vendors (common MRI scanner manufacturers), field strengths, and temporal assessments, which supports the use of this biomarker in large-scale clinical trials.

Learn more about AMRA Medical’s MRI-based services on our website or connect with our team of experts for a detailed discussion at info@amramedical.com.

About AMRA Medical
AMRA Medical is a health informatics company at the forefront of medical imaging and precision medicine. The company has developed a new global standard in body composition analysis, delivering multiple fat and muscle biomarkers with unrivaled accuracy and precision – all from a rapid whole-body MRI scan. AMRA offers clinical services and research services to support transformative care and vital decision-making, from clinical research to clinical care.

Follow AMRA on LinkedIn for the latest updates in body composition and precision medicine.

 

Media Contact AMRA Medical

Marie Börjesson
Senior Director Brand & Marketing
marie.borjesson@amramedical.com
+46 706-281-977

All posts
  • Facebook
  • Twitter
  • LinkedIn
  • Mail
AMRA Medical
Follow us

About

AMRA offers clinical services and research services to support transformative care and vital decision-making, from clinical research to clinical care.

  • Data Privacy Policy
  • Cookie Policy

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Contact

  • info@amramedical.com
  • +46 (0) 13 16 26 00
  • Contact Our Support

Newsletter

© 2025 AMRA Medical AB
AMRA Medical
Manage Cookie Consent
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes. The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
Manage options Manage services Manage {vendor_count} vendors Read more about these purposes
View preferences
{title} {title} {title}
AMRA Medical
Manage Cookie Consent
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes. The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
Manage options Manage services Manage {vendor_count} vendors Read more about these purposes
View preferences
{title} {title} {title}