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Research Services

Musculoskeletal and Neuromuscular Disorder Research Services

Neuromuscular disorders often slowly progress and affect each individual differently, making it difficult to assess drug efficacy quickly and accurately. With AMRA’s MRI scan you can assess 36+ different muscles with precision and detect small changes over time to better evaluate the impact of a drug candidate.

Advance your clinical trials for musculoskeletal and neuromuscular disorders with AMRA’s rapid, whole-body MRI protocol, precise muscle biomarkers, and regulatory strategy support.

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Advance Clinical Research with AMRA® Researcher

We deliver key insights few others can offer—helping our partners make optimal decisions for research and development. Whether you are conducting a complex mechanistic study or a large-scale, international, multi-center imaging trial, we can get you precise muscle and muscle fat replacement measurements for numerous muscles throughout the entire body—tailored to meet your exact needs.

AMRA® Researcher software delivers:

  • Highly accurate, reproducible and precise MR imaging data
  • Global and regional muscle and fat volumes—with accurate anatomical classification
  • Contextual disease insights with individualized data
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Medical Research Services

Earlier Insights and Deeper Knowledge

Conventional tests are often useful, however functional tests lack muscle specificity and can be confounded by various factors (e.g., pain, motivation, etc.), and muscle biopsies are invasive—limiting use and recruitment efforts. With AMRA, you can non-invasively capture objective information about muscle-related diseases and muscle quality and mine that information beyond what is possible with conventional methods. Because our measurements are highly precise, anatomically correct, and can reveal small changes, you can now identify healthy muscles and track if they are remaining healthy!

Drug Impact and Efficacy

We understand that you need to know if your drug candidate works and if it is safe—as efficiently and economically as possible.

Our services can help you detect treatment efficacy and identify non-responders early by capturing small physiological changes throughout the body.

Our whole-body MRI protocol, three muscle biomarkers, and automated image analysis can help you understand the full effect of a drug candidate—for an individual and an individual muscle.

Disease Course and Longitudinal Tracking

Many muscle-related diseases slowly progress over time, and it is important to understand how the disease changes between stages and between individuals to develop effective interventions.

We create solutions that help you capture the full heterogeneity of disease and look at the muscles where you believe there is a progression of disease and at the muscles you want to save (intermediate muscles).

Our standardized whole-body approach gives you a good characterization of various muscle diseases—and different stages within those muscles.

Individualized and Stage-specific

Neuromuscular disorders are infamous for variable onset and progression—making clinical trials and disease research particularly challenging.

AMRA can help you gauge when to shift your assessment from muscles that are wasted—where measurements don’t add value—to other muscles that are healthier, making it easier to detect meaningful changes.

Notably, some muscles are affected earlier than others, and this can vary from patient to patient. We help you identify and include patients in different stages of the disease within the same trial.

For any given study participant, you can determine which muscles need to be assessed and monitored, and can get an idea of when to change course to get the data and insights you need to propel your research forward.

Regulatory Strategy

With precise MR image analysis and extensive experience in regulatory consulting on MRI biomarker strategy, AMRA is a trusted partner for clinical researchers ready to push precision medicine forward with body composition analysis.

AMRA has demonstrated unrivalled expertise in MRI biomarker regulatory strategy. Notably, in neuromuscular disorders (NMD) clinical trial partners are finding AMRA’s services particularly advantageous. Beyond precise, individualized MRI-based muscle biomarkers—which are FDA 21 CFR 11 compliant—AMRA offers strategic regulatory insights for the entirety of a clinical program—from before proof of concept through drug approval for multiple indications, accelerating clinical trials and the path to market approval.

Effortless & Cloud-Based Digital Health

1. Getting Started

Setup & Verification using
AMRA® Protocol

2. Scanning


Rapid MRI

3. Data Transfer

Safe & Secure
Image Transfer

4. Analysis

Automated Segmentation, Quantification & QA

5. Delivery

Body Composition
Spreadsheet

Improve Patient Outcomes and Patient Experience

Rapid Turnaround

Get your imaging results quickly! Our team of experts and automated analysis of multiple measurements gets you results fast.

Easy Collaboration

Our automated, cloud-based analysis facilitates use by multiple research groups—even for multisite research.

Regulatory Compliant

Get results you can trust. Our solutions are 21 CFR Part 11 Compliant and we ensure quality-controlled, secure data transfers.

Global Sites

With 200+ global imaging sites using our protocol, multicenter clinical trials have never been more accessible and seamless.

3 Data-Driven Biomarkers

Get a clear understanding of what is happening in numerous muscles throughout the disease course.

Whole Body MRI

Assess whole muscles throughout the entire body through a single MRI scan—generating accurate and precise insights.

Easy Integration

Easily integrate body composition assessment into your research protocols—tell us what you need and we’ll take care of the rest.

36 Muscles Measured

We help you select the ideal muscles to measure for each individual or at each disease stage for complex musculoskeletal and neuromuscular disorder research.

Our Current Musculoskeletal & Neuromuscular Disorder Research Areas

Is Your Research Area Not Listed? We can still support you! Contact Us to learn more.

FSHD

DMD

LGMD

Myotonic Dystrophy

Mitochondrial Myopathy

SBMA

SIBM

Pompe

With AMRA, you gain access to whole-body, whole-muscle volumetric analysis of 36+ muscles from a single MRI—saving you time and resources to help you accelerate your path to market.

What you get

Confidently Assess Muscles with Whole-Body MRI

Conventional imaging methods only look at certain body parts, or parts of single muscles, which can create a skewed idea of what is actually going on inside the body. AMRA looks at the whole-body and at whole muscles—giving you a more complete picture of the muscles you need to assess.

  • Lean Muscle Volume (LMV)
  • Muscle Fat Infiltration (MFI)
  • Muscle Fat Fraction (MFF)

Case Study

Image Analysis for a FSHD Clinical Trial

Different muscles are affected by FSHD in different ways. AMRA’s whole-body MRI analysis can capture FSHD heterogeneity. Learn how whole-body MRI measurements can potentially take the subjectivity out of measuring change over time in research studies.

Read more

Derisk Drug R&D for Musculoskeletal Disorders

Need imaging analytics or clinical trial support? Explore our comprehensive research services from pilot study through commercialization. Our team of MRI and clinical experts can help you design your clinical protocol, explore different biomarkers, and interpret your MRI measurements.

Explore

Resources

Publications

MRI in Neuromuscular Diseases: An Emerging Diagnostic Tool and Biomarker for Prognosis and Efficacy

Webinar

Whole-body MRI in FSH Muscular Dystrophy Research

Webinar

Muscle Fat Replacement and Functional Decline in Neuromuscular Disorders – Quantitative Skeletal Muscle MRI in Clinical Trials

Webinar

Demystifying MRI for Body and Muscle Composition in Multi-Center Global Clinical Trials

Let’s talk

Tell us how you are using MRI for body composition analysis and let’s power the future of medicine together.

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Latest news

  • AMRA Medical Launches AMRA® Profiler 4 in Sweden and Germany, Kickstarting Availability Campaign of AMRA® BCP Scan Service in the EU

    May 13, 2025
  • Latest Data from SURPASS-3 Trial Gleans Insight Into the Association of Tirzepatide Treatment with Changes in Muscle Composition in Type 2 Diabetes 

    May 1, 2025

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AMRA offers clinical services and research services to support transformative care and vital decision-making, from clinical research to clinical care.

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