LINKÖPING, Sweden; October 25, 2019 – Dr. Mikael F Forsgren, Senior Scientist at AMRA Medical and researcher at Linköping University’s Centre for Medical Image Science and Visualization, collaborated with scientists at Virginia Commonwealth University to assess metabolic flexibility and skeletal muscle function in 19 patients that received a liver transplant for either NASH or non-NASH cirrhosis and will present their findings at AASLD’s The Liver Meeting® in Boston.
Patients that have received a liver transplant for NASH cirrhosis have greater weight gain post-transplant compared with those with non-NASH cirrhosis and Dr. Mohammad Shadab Siddiqui and colleagues reveal that it may be related to a reduced ability to use fatty acids as biofuels.
AMRA® Researcher MRI technology was used to assess body composition and the researchers found that there was a strong inverse relationship between metabolic flexibility – the ability to use available biofuels such as fatty acids for energy – and muscle fat infiltration. Thus supporting the idea that increased weight gain in patients that received a liver transplant for NASH cirrhosis is likely a result of reduced metabolic flexibility.
This study will be presented in detail next month at The Liver Meeting® on November 10, 2019 in Boston by Dr. Mohammad Shadab Siddiqui.
Abstract Title : Patients Transplanted for NASH Cirrhosis Have Impaired Whole Body Fatty Acid Oxidation
Authors: Mohammad Shadab Siddiqui, Sherry Boyett, Mikael Forsgren, Samarth Patel, Shanshan Chen, Mohammad B Siddiqui, Chandra Bhati, Arun J Sanyal, Carolyn J. Driscoll, and Francesco Celi
Publication Number: 0093
Session Title: Parallel 11: Liver Transplant: Renal and Metabolic Issues
Presentation Type: Oral presentation, Parallel Session
Session Date and Time: Sunday, November 10, 2019, 2:00 PM
Presentation Time: 2:30 PM
Location: Room 304/306, Hynes Convention Center
Attend this presentation and connect with AMRA at AASLD’s The Liver Meeting® in November to learn more about our team, research, and technology. The abstract can be found in the abstract book published in Hepatology (Siddiqui MS, et al. [Abstract] Hepatology 2019;70(Suppl.1):63A)
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