Imaging biomarkers bring a tremendous value to clinical trials. They provide an objective means of noninvasively assessing the study participants’ physiological status. These biomarkers can be used for various purposes, ranging from inclusion criteria to measuring treatment response and monitoring adverse reactions. Magnetic resonance imaging (MRI) is the gold standard imaging modality for examining soft tissues such as muscles, fat, and organs. In addition to providing excellent contrast between different types of soft tissue, MRI is a safe, patient-friendly, and noninvasive imaging modality free from ionizing radiation. MRI is widely available globally but sometimes perceived as challenging to implement in clinical trials, especially in multi-site settings. This webinar will challenge that myth.
In the first part of the webinar, an MRI site training specialist from Philips BioTel Research, an imaging contract research organization, will share her experience of how to successfully use MRI in clinical trials. This will highlight the clinical trial research team, best practices, and important considerations for the usage of MRI. Global multi-site settings, where site training, protocol standardization, and quality control are keys to success, will be emphasized. A firsthand look at MR imaging in a clinical trial from the imaging facility’s point of view will be included.
In the second part, an imaging scientist from AMRA Medical will discuss quantitative MRI biomarkers for body composition analysis. It is increasingly understood how a person’s fat distribution and muscle composition are helpful for risk assessment, diagnosis, and prognosis in a multitude of diseases including muscular dystrophies, sarcopenia, obesity, liver disease, type 2 diabetes, and cardiovascular disease. To successfully use quantitative imaging biomarkers in large-scale studies, high accuracy and precision have to be achieved in conjunction with extensive automation. Therefore, measures that can be taken both on the image acquisition and the image analysis side will be reviewed.
Join this free webinar where you will learn about the simplicity, cost-efficiency, and overall effectiveness of MRI biomarkers in clinical research!