Interested in how liver transplantation affects your patient’s body composition?
Dr. Mohammad S. Siddiqui (Virginia Commonwealth University) presented novel results from a study that evaluated the body composition of individuals with cirrhosis caused by nonalcoholic steatohepatitis (NASH) or other factors (non-NASH) that received liver transplantation (LT), using MRI and AMRA´s technology.
The results revealed that an increase in visceral and subcutaneous fat and a less beneficial muscle phenotype (a combination of high muscle fat infiltration and low muscle volume) were recorded in the LT-recipients compared to controls from the general population. These findings were exaggerated in the subgroup of participants that received a LT because of NASH cirrhosis. These are novel insights into the metabolic risk after liver transplantation and support the potential to develop metabolic risk stratification strategies in this patient population.
Full abstract available soon: “THE IMPACT OF LIVER TRANSPLANTATION AND NONALCOHOLIC STEATOHEPATITIS ON BODY COMPOSITION”
Assessing muscles in liver disease is key
Dr. Omar Jamil, University of Chicago presented interesting interim study findings including measurements provided by AMRA® MAsS Scan, powered by AMRA® Profiler 4.
The study revealed the prevalence of high muscle fat infiltration and low muscle volume in patients with end-stage liver disease using the MRI-based AMRA® MAsS Scan. A state, referred to as adverse muscle composition in literature, was identified by using muscle fat infiltration (associated with muscle quality) and muscle volume z-score (describing quantity), and was prevalent in 16% of the study population, ambulatory patients not previously diagnosed with frailty or sarcopenia. Adverse muscle composition has in literature been linked to components of frailty and sarcopenia, and has been shown to be an independent predictor of all-cause mortality.
Full abstract available soon: “High Prevalence of Clinically Unrecognized Low Muscle Volume as Assessed by Novel MRI-Based Muscle Assessment Technology”
AMRA® MAsS Scan provides standardized measurements of muscle composition which may support the clinician in their decision-making and identification of vulnerable patients.
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